Genetic Toxicology & Photosafety Industrial Placement

by GSK

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Deadline: 15th December 2020
Salary: Competitive
Length: Placement (10 Months+)
Roles: Medicine, Pharmaceutical, Science
Location: East of England
City: Ware

Genetic Toxicology & Photosafety Industrial Placement

Before regulatory authorities will grant permission for administration of potential new pharmaceuticals, they require that the safety of the substance has been assessed in a battery of nonclinical safety tests. Genotoxicity tests can be defined as in silico, in vitro and in vivo tests, designed to detect compounds that induce genetic damage by various mechanisms, e.g. mutations, structural and numerical chromosomal damage. The genetic toxicology unit undertakes a variety of research projects to evaluate innovative in vitro technologies to investigate these mechanisms of genetic damage, which is an important component of human risk assessment.

Students undertaking a placement in genetic toxicology will perform a research project to consist of literature review and the establishment of expertise in one or more of the following technologies: mammalian cell culture, flow cytometry, microscopy and image analysis. Following appropriate training, students will be expected to conduct independent research and collate and analyse experimental data, write reports/summaries and a dissertation at the end of year. They will also be expected to present the results of their work at the annual students review and external meetings, as appropriate.

In addition, working alongside experienced genetic toxicology experts, students will develop knowledge of the drug development process and the role of safety assessment and genetic toxicology; be involved in general laboratory management duties throughout the year to gain valuable experience in the daily workings of an industrial genetic toxicology lab to directly support the screening of potential new medicines; develop scientific, IT and other core skills.

About GSK

One of the world’s leading healthcare companies, GSK discovers, develops, manufactures and distributes life-saving vaccines, prescription medicines and consumer health products such as Maxinutrition, Sensodyne, Aquafresh and Panadol.

The size and scope of our organisation allows our people to answer some of the biggest questions facing everyone on the planet – questions about future healthcare needs and questions about building a responsive, innovative, global business to meet them – as well as questions about their own personal and professional growth.

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